During the first reporting meeting of ProteomeBinders (12.-13. 3. 2007), project partners updated themselves on the progress of the project and discussed the group's future strategies. Quality control of binding molecules was agreed to be a crucial subject, on which activities should be focussed in a follow-on project.
The Affinity Proteomics workshop (13.-15. 3. 2007) was jointly organised by ProteomeBinders and
MolTools, and supported by the European Science Foundation
Functional Genomics Programme.
The workshop explored the technologies and reagents required for affinity proteomics and provided training in background and application of affinity methods for graduate students and postdocs. In addition to the partners from the ProteomeBinders and MolTools consortia, academics and industry representatives from Europe and the United States participated.
In beautiful weather, mid-day time was set aside for skiing and other alpine activities.
Programme Overview and Meeting Brochure:
Click here for a
programme overview or the
meeting brochure.
Presentations for viewing and downloading in pdf-format:
Wednesday, 14. 3. 2007:
Session 1 - Overview of the Human Proteome
Matthias Wilm (EMBL, Heidelberg): Proteomics is chasing the time line
Mathias Uhlén (KTH, Stockholm): A human protein atlas for normal and cancer tissues
Andreas Plückthun (University of Zurich): Specific binders against integral membrane proteins
Session 2 - Bioinformatics Infrastructures for Proteomics
Lydie Lane (Swiss Institute of Bioinformatics, Geneva): The UniProtKB-Swiss-Prot Human Proteomic Initiative (HPI)
Session 3 - Antibodies and Alternative Binders
Ronald Frank (HZI, Braunschweig): ProteomeBinders link to Chemical Biology
Larry Gold (Somalogic, Boulder CO): SomaLogic's progress with aptamer-based proteomic arrays
Arne Skerra (TU Munich): Anticalins and other alternative scaffolds for molecular recognition of proteome targets
Stefan Dübel (TU Braunschweig): The German NGFN Antibody Factory
Andrew Bradbury (LANL, LosAlamos, NM): Recognising post-translational modifications: the sulfotyrosine example
Carl Borrebaeck (University of Lund): Detecting cancer with recombinant antibody microarrays
Thursday, 15. 3. 2007:
Session 1 - Affinity Tools and Methods
Thomas Laurell (University of Lund): On-chip affinity probing by fluorescence and MALDI MS
Christof Niemeyer (University of Dortmund): Semisynthetic DNA-Protein conjugates for diagnostic applications
Ulf Landegren (University of Uppsala): Assay formats for enhanced protein analyses
Session 2 - Intrabodies
Terence Rabbitts (MRC, Cambridge): Interfering with protein-protein interactions in cancer cells
Silvère van der Maarel (Leiden University Medical Centre): Single domain antibody fragments for biomedical applications
Heinrich Leonhardt (University of Munich): Targeting and tracing of antigens in living cells with fluorescent nanobodies
Session 3 - Applications and Quality Control
Eric Chevet (University of Bordeaux): Alphascreen - principles and applications
André Bernard (NTB, Buchs): Affinity contact printing and compact disc readers for protein patterning and affinity sensing
Markus Templin (NMI, Tübingen): Binder characterisation and quality control: specificity, affinity, cross-reactivity
Session 4 - Biomolecular resources
Leena Peltonen (University of Helsinki): Large scale population studies: Any new opportunities provided by FP7?
Kurt Zatloukal (Medical University of Graz): European Research Infrastructure
for Biobanking and Biomolecular Resources
Martin Yuille (University of Manchester): Building research infrastructure for big biology: experiences from the UK
Session 5 - Large Binder Projects - Future Directions
Adam Clark (NCI, Bethesda, MD): The NCI’s Clinical Proteomic Technologies Initiative for Cancer
Michael Lisurek (FMP, Berlin): ChemBioNet - Chemical biology supported by a network of chemists and biologists
Local Information
For those of you reminiscing about the meeting: a full map of Alpbach in pdf format can be downloaded
here.
